METHOXYFENOZIDE First draft prepared

Explanation.................................................................................................... 161 Evaluation for acceptable daily intake .......................................................... 161 Biochemical aspects ................................................................................ 162 Absorption, distribution and excretion .............................................. 162 Biotransformation .............................................................................. 165 Dermal absorption.............................................................................. 168 Toxicological studies ............................................................................... 168 Acute toxicity ..................................................................................... 168 General toxicity ............................................................................ 168 Ocular and dermal irritation and dermal sensitization ................ 168 Short-term studies of toxicity ............................................................ 169 Oral administration....................................................................... 169 Dermal exposure........................................................................... 180 Long-term studies of toxicity and carcinogenicity............................ 182 Genotoxicity ....................................................................................... 188 Reproductive toxicity ......................................................................... 189 Multigeneration study................................................................... 189 Developmental toxicity................................................................. 192 Special studies.................................................................................... 194 Acute neurotoxicity in rats ........................................................... 194 Thirteen-week study of neurotoxicity in rats............................... 195 Studies on metabolites.................................................................. 196 Observations in humans .......................................................................... 196 Comments...................................................................................................... 196 Toxicological evaluation................................................................................ 199 References ..................................................................................................... 201